Correlation between the characteristics of ultrasonic contrast and the regional distribution of tumor vascular heterogeneity in breast cancer

To clarify the correlation between qualitative and quantitative parameters of contrast-enhanced ultrasound regional distribution differences microvessel density (MVD) vasculogenic mimic (VM) in breast cancer. 119 female patients with suspected cancer were involved. The clinicopathological collected. Contrast-enhanced was performed on patients. After operation, according to unified standard, marginal zone, central region paracancerous area sampled respectively. MVD labeled by immunohistochemistry CD34, tumor VM CD34/PAS double staining. distributions decreased (P < 0.05, respectively), but correlations MVD, not consistent. zone correlated MVD. positive rate also higher when mass larger clinical stage higher. When histological grade high, rates three regions high. better than that VM, associated more prognostic factors